RAGs and regulation of autoantibodies.
نویسندگان
چکیده
Autoreactive antibodies are etiologic agents in a number of autoimmune diseases. Like all other antibodies these antibodies are produced in developing B cells by V(D)J recombination in the bone marrow. Three mechanisms regulate autoreactive B cells: deletion, receptor editing, and anergy. Here we review the prevalence of autoantibodies in the initial antibody repertoire, their regulation by receptor editing, and the role of the recombinase proteins (RAG1 and RAG2) in this process.
منابع مشابه
Thyroid autoantibodies in chronic urticaria: A case-control study in a South Indian population
Background: Chronic urticaria (CU) is a common skin disorder that accounts for 15%-20% of dermatological cases. There is growing evidence that some cases of chronic idiopathic urticarial (CIU) are associated with various autoimmune diseases, including thyroid autoimmunity. This study aims to identify the thyroidprofile, including thyroid autoantibodies, in patients with CU.Methods: This case-co...
متن کاملA Systems Approach to Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily attacks synovial joints. Despite the advances in diagnosis and treatment of RA, novel molecular targets are still needed to improve the accuracy of diagnosis and the therapeutic outcomes. Here, we present a systems approach that can effectively 1) identify core RA-associated genes (RAGs), 2) reconstruct RA-perturbed networ...
متن کاملObject-Oriented Declarative Program Analysis
This thesis deals with techniques for raising the programming level for a particular kind of computations, namely those on abstract syntax trees. Such computations are central in many program analysis tools, such as compilers, smart languagesensitive editors, and static analysis tools. All techniques presented in this thesis support modular description and efficiency and are capable of handling...
متن کاملApplications and Extensions of Reference Attributed Grammars
This thesis deals with techniques for raising the programming level for a particular kind of computations, namely those on abstract syntax trees. Such computations are central in tools that manipulate programs, e.g., compilers, smart language-sensitive editors, software metric tools, etc. Our work is based on Reference Attributed Grammars (RAGs) which combines object-oriented features with decl...
متن کاملUsing Semantic Web Technology to Support NLG. Case Study: OWL finds RAGS
The semantic web is a general vision for supporting knowledge-based processing across the WWW and its successors. As such, semantic web technology has potential to support the exchange and processing of complex NLG data. This paper discusses one particular approach to data sharing and exchange that was developed for NLG – the RAGS framework. This was developed independently of the semantic web....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Annual review of immunology
دوره 22 شماره
صفحات -
تاریخ انتشار 2004